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US Dept of Defense – Battlefield Wound Management and Infection Research Award – W81XWH-22-S-DMRDP-BWMIR

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US Dept of Defense – Battlefield Wound Management and Infection Research Award – W81XWH-22-S-DMRDP-BWMIR

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  • Supports research that will increase the understanding of complex wound physiology and infection control, in order to support future application and maturation of products, technologies, and clinical practice
  • Supports applied and preclinical research, clinical research, and small-scale clinical trials (eg, first in human, phase 1/1b)
  • Fundamental basic research, phase 2/3 clinical trials are not supported under this funding opportunity
Focus Areas:
  • Understanding appropriate wound prophylaxis/empiric treatment strategies throughout continuum of care, regardless of injury status, through preclinical and clinical studies to inform clinical practice guidelines for:
    • Managing hemorrhagic shock/super-massive transfusion, traumatic limb ischemia (secondary to vascular disruption or tourniquet use), complex soft tissue injury/blast injury, open fracture, and/or frost bite, including evaluation of antimicrobial dosing and tissue penetration studies.
    • Expanding the understanding of antibiotic use in tissue injury (e.g., systemic versus topical), especially in the context of hemorrhage/resuscitation, blast, and/or delayed evacuation times
  • Understanding combat traumatic wound physiology and wound progression through preclinical and clinical studies to inform clinical practice guidelines and standard of care efficacy and gaps.
  • Optimizing prolonged care management of penetrating torso injury by developing solutions for prevention/management of deep space infections (eg, bacterial or fungal) and delays in care of penetrating abdominal injury.
  • Development of analysis and decision support tools to guide traumatic combat wound care and casualty management to triage, prevent and/or treat infections. Examples include:
    • Technologies to determine the types of wound infections at risk of progression to complications and sepsis;
    • Tools to evaluate tissue status before devitalization; and
    • Guided triage/intervention techniques to be used by front-line providers at early stages of care
– Letter of intent due 20 October 2022 – up to USD$1.2M over 3 years (FL1) or USD$2.2M over 4 years (FL2)  W81XWH-22-DMRDP-BWMIR-BAA-GG

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