DARPA’s Defense Sciences Office is seeking innovative proposals that leverage emerging neuromodulation technologies to enhance sleep efficiency and performance under sleep-restricted conditions.
RESTORE aims to develop multimodal, multitarget, noninvasive neuromodulation methods to repair disrupted sleep architectures caused by sleep restriction, with the ultimate goal of improving cognitive performance. Interventions should optimize performance within a sleep restriction environment characterized by 3 hours of sleep over an acute period of 3-7 days.
RESTORE is a 24-month, single-phase program focused on demonstrating precision control of sleep’s macro- and micro-architectures to enhance whole-brain sleep.
Performers will be conducting Human Subjects Research (HSR) and must plan for primary Institutional Review Board (IRB) and secondary review by the U.S. Army Medical Research and Development Command (USAMRDC) Office of Human and Animal Research Oversight (OHARO), required for Government-sponsored HSR in the proposed cost and schedule. No HSR data collection can begin prior to OHARO approval.
Key Technical Objectives
- Develop a multimodal system that enables the precision control and optimization of sleep macro- and micro-architectures
- Evaluate changes in sleep macro- and micro-architectures and their mediating effects on pre- and post-intervention brain activity, sleep and cognitive performance
Abstracts (strongly encouraged but not mandatory) are due 14 April 2025.
Full proposals are due 18 June 2025.
Document
BAA – RESTORE: HR001125S0012
