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US Dept of Defence – Vision Research Program

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US Dept of Defence – Vision Research Program


Investigator-Initiated Research AwardHT9425-23-VRP-IIRA

  • up to USD$260,000 over 2 years (funding level 1) or up to USD$750,000 over 3 years (funding level 2)
  • pre-applications due 14 July 2023
  • supports studies that will yield highly impactful discoveries or major advancements in the research and/or patient care of eye injury and/or visual dysfunction as related to military exposure.
  • Funding level 1 – supports exploratory, innovative, high-risk/high-reward research that is in the earliest stages of idea development. Research must have the potential to yield new avenues of investigation, such as new approaches, new research tools, or new paradigms.  Preliminary data not required.
  • Funding level 2 – supports the advancement of more mature research toward clinical translation. The research idea or solution should be innovative or novel, or offer significant refinements, improvements, or new applications of existing ideas or solutions, as applicable.  May focus on any phase of research from basic through translational.  Preliminary data required.
  • clinical trails not allowed
  • Must address one or more Focus Areas

Translational Research Award –

  • up to USD$1M over 3 years
  • pre-applications due 14 July 2023
  • supports translational research that moves promising discoveries into clinical applications that will advance the prevention, diagnosis, mitigation, and/or treatment of eye injury or visual dysfunction associated with military exposure.
  • applications should establish a clear path to transforming a promising discovery into new drugs, devices, or clinical practice guidelines that are ready for definitive testing in clinical trials. For new drug or device development, the investigative team should include at least one collaborator with expertise in the regulatory approval process.
  • Pilot clinical trial component is allowed. Full-scale clinical trials are not allowed.
  • Animal, human subject and human anatomical substance research is allowed


Clinical Trial AwardHT9425-23-VRP-CTA

  • up to USD$1.6M over 3 years
  • pre-applications due 14 July 2023
  • supports the rapid implementation of early-phase clinical trials (ie phase 0 through phase 2a) of new interventions with the potential to have a significant impact on the treatment or management of service-connected eye injury and visual dysfunction.
  • Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies
  • must address one or more Focus Areas

Focused Translational Team Science Award 

  • up to USD$4M over 4 years
  • pre-applications due 14 July 2023
  • support a highly collaborative and translational team initiative that will fundamentally advance the understanding and treatment of eye injury and/or visual dysfunction that result from military exposure (eg blast, blunt, thermal, chemical, directed energy trauma).
  • Applications shall include at least three but no more than five distinct research projects that together form a concerted and synergistic effort to address the overarching challenge.
  • must address one or more Focus Areas

Mentored Clinical Research Award –

  • up to USD475,000 over 18 months
  • pre-applications due 8 August 2023
  • supports patient-oriented vision injury research and develop research expertise of highly motivated military/civilian physicians-in-training. Research supported by the MCRA can be a standalone study of high impact to vision injury care or the generation of clinical research data in preparation for a more expansive study.
  • Each MCRA must be led by an established clinician or Ph.D. clinical scientist who will serve as Principal Investigator (PI) of the award. Key personnel must include a physician-in-training (eg fellows, residents, junior clinician) with at least 18 months remaining in their training program. The physician-in-training will conduct the proposed research under the mentorship of the PI, with support from supporting personnel as appropriate.
  • cannot be used to conduct preclinical research (including animal research) or clinical trials
  • funding can be used for salary support for support personnel (not the mentee or mentor); travel to present at one scientific/technical meeting
  • must address one or more Focus Areas

Vision Research Program Focus Areas

  • Understanding and treatment of eye injury or visual dysfunction as related to military exposure.
  • Diagnosis, stabilization, and treatment of eye injuries in austere environments and prolonged field care settings
  • Restoration of visual function after military exposure-related vision loss or severe visual impairment


Supporting Documents

Investigator-Initiated Research Award: HT9425-23-VRP-IIRA_GG

Translational Research Award:HT9425-23-VRP-TRA_GG

Clinical Trial Award: HT9425-23-VRP-CTA_GG

Focused Translational Team Science Award: HT9425-23-VRP-FTTSA_GG

Mentored Clinical Research Award:HT9425-23-VRP-MCRA_GG