US Dept of Defense – Chronic Pain Management Research Program

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Clinical Exploration Award – HT9425-23-CPMRP-CEA

up to USD$250,000 over 2 years
Pre-proposals due 21 August 2023
Supports early-phase, proof-of-principle clinical trials and correlative studies, particularly those including complementary and integrative health methods.
explorative studies, innovative approaches and stakeholder engagement encouraged
must address chronification of pain and effectiveness or observational studies of novel or untested techniques/approaches/pathways to chronic pain management
preliminary data not required
studies evaluating opioid-based therapeutic interventions not allowed

Investigator-Initiated Research Award – HT9425-23-CPMRP-IIRA

up to USD$900,000 over 4 years
Pre-proposals due 21 August 2023
Supports innovative research that will make an original and important contribution to the field of research, patient care, and/or quality of life.
Multidisciplinary collaborations, innovative approaches, and stakeholder engagement are encouraged.
must address chronification of pain or development of non- opioid therapies and methods of treatment of chronic pain.
clinical trials not allowed

Clinical Outcomes Research Award – HT9425-23-CPMRP-CORA

up to USD$1.4M over 4 years
Pre-proposals due 21 August 2023
Supports acceleration of evidence-based ideas and research into clinical applications (eg health care products, technologies, practice guidelines, models of care).
Key stakeholder engagement throughout the research process is highly encouraged
must address comparative effectiveness for evidence-based, efficacious interventions to manage or prevent chronic pain, implementation science for evidence-based efficacious interventions to manage or prevent chronic pain, observational studies related to chronic pain, or relationships between comorbidities and pain.
preliminary and/or published data required
studies evaluating opioid-based therapeutic interventions not allowed
animal studies not allowed

Pain Management Collaborative Clinical Research Award – HT9425-23-CPMRP-PMCCRA

up to USD$500,000 over 15 months (base period) plus up to USD$3M over 3 years (clinical trial phase)
pre-proposals due 21 August 2023
Supports large-scale clinical trials that promote acceleration of evidence-based ideas and research into clinical applications (e.g., health care products, technologies, practice guidelines, models of care).
Participation in working groups and cross project initiatives is expected.
Key stakeholder engagement throughout the research process is highly encouraged.
preliminary and/or published data required

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