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US Dept of Defense – Melanoma Research Program

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US Dept of Defense – Melanoma Research Program

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  • Idea Award – W81XWH-22-MRP-IA – up to USD$500,000 over 3 years – Pre-applications close 8 July 2022 – supports new ideas that represent innovative, high-risk/high-gain approaches to melanoma research that are beyond an incremental advancement. Emphasis on innovation & impact. Must address at least one Focus Area.
  • Melanoma Academy Scholar Award – W81XWH-22-MRP-MASA – up to USD$550,000 over 3 years – Pre-applications close 14 September 2022 – must be within 7 years of PhD award – supports the addition of new Scholars to the unique, interactive virtual academy that provides intensive mentoring, national networking, collaborations, and a peer group for early-career melanoma investigators/faculty – A Career Guide who is an experienced melanoma researcher with melanoma cancer funding is required (Career Guide does not have to be at the same institution) – Must address at least one Focus Area.
  • Mid-Career Accelerator Award – W81XWH-22-MRP-MCAA – up to USD$725,000 over 3 years – Pre-applications due 14 September 2022 – Assistant or Associate Professors at least 7 years post first faculty appointment – supports mid-career researchers to conduct impactful melanoma research – must show evidence of at least one peer-reviewed external funding award – preliminary data relevant to melanoma required – must address at least one Focus Area
  • Team Science Award – W81XWH-22-MRP-TSA – up to USD41M over 3 years – Pre-applications due 14 September 2022 – At least 2, up to 3 investigators partnering in one overarching multi-disciplinary research study – Assistant Professor and above – new or existing partnerships – emphasis on synergy, multi-disciplinary research and impact – particularly keen on studies involving correlation associated with clinical trials; analysis of large/complex melanoma datasets; bioengineering approaches to address diagnostics, high risk markers, dormancy, metastasis – must address at least one focus area
  • Focused Program Award – Rare Melanoma – W81XWH-22-MRP-FPA – up to USD$2M over 4 years – Pre-application due 14 September 2022 – Applications may propose research across the entire spectrum (biology, etiology, prevention, diagnosis and detection, prognosis, treatment, and quality of life) and must address a critical unmet need relevant to rare melanomas (uveal, acral, mucosal, pediatric, etc.). – Supports a synergistic, multidisciplinary research program of at least two, but not more than three, distinct but complementary projects addressing an overarching question relevant to rare melanomas.

    2022 MRP Focus Areas
  • Research across the entire spectrum (biology, etiology, prevention, diagnosis and detection, prognosis, treatment, and quality of life) for rare melanomas (eg uveal, acral, mucosal, pediatric) in patients and model organisms.
  • Identify and understand risk factor determinants for melanoma, including rare subtypes.
  • Develop prediction and surveillance tools for distinguishing patient populations at risk for second primary/recurrence and/or metastasis.
  • Understand how precursor lesions and environmental/endogenous factors influence melanomagenesis, including (but not limited to) race, sex as a biological variable, etc.
  • Develop new tools for the detection and diagnosis of melanoma, which includes easily accessible technology (beyond the dermoscope) for primary care physicians and dermatologists.
  • Identify how the tumor microenvironment (e.g., stromal, immune, microbiome) impacts tumor initiation, response to therapy, progression, recurrence, and/or dormancy.
  • Delineate the molecular pathways that influence metastatic spread, recurrence, and/or dormancy.

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