US Dept of Defense – Neurofibromatosis Research Program

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Clinical Trial Award – HT9425-23-NFRP-CTA

up to USD$800,000 over 4 years
letters of intent due 11 August 2023
supports research with the potential to have a major impact on the treatment or management of NF.
must support a clinical trial (phase 0, 1, or 2 clinical trials relevant to NF or schwannomatosis; combinations of phases permitted)
preliminary data required for phase 1 or 2 clinical trial applications
pre-clinical studies not allowed

Exploration-Hypothesis Development Award – HT9425-23-NFRP-EHDA

up to USD$100,000 over 2 years
letters of intent due 11 August 2023
Supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in NF research.
preliminary and/or published data encouraged but not required
mentorship highly encouraged
clinical trials not allowed

Early Investigator Research Award – HT9425-23-NFRP-EIRA

up to USD$200,000 over 2 years
letters of intent due 11 August 2023
Supports NF-focused research opportunities for individuals in the early stages of their careers.
must be involved in postdoc training or medical residency program
must have up to 4 years continuous postdoc research experience
must have a designated mentor who is an experienced NF researcher
clinical trials not allowed

Investigator-Initiated Award – HT9425-23-NFRP-IIRA

up to USD$525,000 over 3 years
letters of intent due 11 August 2023
Supports highly rigorous, high-impact research projects that have the potential to make an important contribution to NF research and/or patient care.
preliminary and/or published data required
clinical trials not allowed

Synergistic Idea Award – HT9425-23-NFRP-SIA

up to USD$2M over 3 years
letters of intent due 11 August 2023
Supports new or existing partnerships involving 2 or 3 PIs to address a central innovative question or problem in NF that may include high risk, provided there is a potential for significant impact.
Application must demonstrate the synergistic components (i.e., leveraging disciplines, expertise, or critical resources) that will significantly advance the project such that the research outcomes as a whole will be realized rapidly and efficiently and could not otherwise be accomplished through the independent efforts of a single investigator
preliminary and/or published data required
clinical trials not allowed

New Investigator Award – HT9425-23-NFRP-NIA

up to USD$450,000 over 3 years
letters of intent due 11 August 2023
ESI – Supports research conducted by promising independent investigators; at or below Assistant Professor level or equivalent
EI – Supports the transition of established investigators who will transition from other research fields into a career in NF research; above Assistant Professor level
prior experience in NF research not required
preliminary and/or published data not required
clinical trials not allowed

Supporting Documents

Synopsis of FY23 NFRP Award Mechanisms: 23nfrpreftable

Exploration-Hypothesis Development Award: HT9425-23-NFRP-EHDA PA_GG

Early Investigator Research Award: HT9425-23-NFRP-EIRA PA_GG

Investigator-Initiated Award: HT9425-23-NFRP-IIRA PA_GG