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US Dept of Defense – Spinal Cord Injury Research Program

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US Dept of Defense – Spinal Cord Injury Research Program


Pre-proposals due 24 May 2023


Clinical Trial Award HT9425-23-SCIRP-CTA

  • up to USD$3M over 4 years
  • supports rapid implementation of clinical trials with potential to have significant impact on treatment or management of spinal cord injury
  • projects may range from small proof-of-concept trials to demonstrate feasibility or inform the design of more advanced trails, through large-scale trials to determine efficacy in relevant populations
  • applications are expected to name at least 2 community partners
  • preliminary data required

Clinical Translation Research Award  – HT9425-23-SCIRP-CTRA

  • up to USD$1.25M over 3 years
  • supports high-impact and/or new/emerging clinical research that may not be ready for a larger-scale clinical trial and for which feasibility/pilot studies are necessary.
  • studies may be interventional or observational and may involve some
    retrospective data analysis BUT purely retrospective or database-related research will not be supported
  • research may consist entirely of a small/pilot clinical trial.
  • applications are expected to name at least 2 community partners
  • preliminary data required

Translational Research AwardHT9425-23-SCIRP-TRA 

  • up to USD$1.25M over 3 years
  • Funds studies that accelerate the movement of promising ideas in SCI research into clinical applications.
  • May include a pilot clinical trial ONLY as a part of the proposed research where limited clinical testing of a novel intervention or device is necessary to inform the next step in the continuum of translational research.
  • applications are expected to name at least 1 community partner
  • preliminary data required

Investigator-Initiated Research AwardHT9425-23-SCIRP-IIRA

  • up to USD$500,000 over 3 years
  • Funds research that has the potential to make an important contribution to SCI research, patient care, and/or quality of life.
  • Permitted research includes preclinical studies in animal models, research with human subjects, or human anatomical substances, as well as ancillary studies associated with an existing clinical trial.
  • studies focused exclusively on target identification are discouraged
  • clinical trials not allowed
  • preliminary data required

2023 Focus Areas

  • preserving & protecting spinal cord tissue at time of injury for improved neurologic outcomes
  • identifying 7 validating biomarkers for diagnosis, prognosis and evaluation of treatment efficacies
  • developing, testing, and validating promising interventions to address bowel, genitourinary, neuropathic pain, cardiopulmonary, or autonomic dysfunction in people with SCI
  • investigating psychosocial issues relevant to people with SCI, their families, and/or their care partners
  • rehabilitation and regeneration—maximizing the function of the residual neural circuitry, including harnessing neuroplasticity and recovery to improve function after SCI

Supporting documents for download




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