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US Dept of Defense – Traumatic Brain Injury & Physiological Health Research Program

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US Dept of Defense – Traumatic Brain Injury & Physiological Health Research Program

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Investigator Initiated Research Award – W81XWH-22-TBIPHRP-IIRA – up to USD$500,000 over 3 years – letter of intent due 24 August 2022 – supports research that will make an important contribution toward understanding, preventing, assessing and treating psychological health and/or TBI conditions – clinical trials not supported
Translational Research Award – W81XWH-22-TBIPHRP-TRA – up to USD$1M over 3 years – letter of intent due 24 August 2022 – supports translation of promising research into clinical application (ie pre-clinical to clinical translation) – may support small-scale pilot clinical trial when necessary to inform next step in clinical development
Patient-Centered Research Award – W81XWH-22-TBIPHRP-PCRA – up to USD$1M over 3 years – letter of intent due 24 August 2022 – supports research to bridge the gap between research, practice and policy by building a knowledge base on how interventions and clinical practices/guidelines and policies can be deployed to target populations at the appropriate time at the point of need – must support clinical trials – cannot be used for pre-clinical or animal research – must include community-based participatory research approaches.
Clinical Trial Award – W81XWH-22-S-TBIPH1 – preproposals due 1 September 2022 – supports rapid implementation of clinical trials with the potential to have a significant impact on psychological health and/or TBI through clinical applications including healthcare products, technologies and/or practice guidelines
  • Research Level 1 – up to USD$500,000 over 3 years – proof-of-principle pilot trials, correlative studies and other innovative, exploratory clinical trials
  • Research Level 2 – up to USD$2M over 4 years – clinical trials for promising treatments or interventions that have already demonstrated acceptable safety in human subjects
  • Research Level 3 – up to USD$4M over 4 years – large-scale clinical trials to demonstrate efficacy in relevant patient populations
Focused Program Award – W81XWH-22-S-TBIPH2 – USD$5M over 4 years – preproposals due 1 September 2022 – supports a synergistic, multi-disciplinary research program of at least 4 distinct but complimentary projects addressing an overarching goal – individual projects must be capable of standing on their own high scientific merits. They must also be inter-related, synergistic and align with the overarching challenge to advance a solution beyond what would be possible through individual efforts – individual projects may include applied research, pre-clinical research, clinical research and clinical trials, but should NOT include basic research.

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