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US Dept of Defense – Bone Marrow Failure Research Program

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US Dept of Defense – Bone Marrow Failure Research Program

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Idea Development Award HT9425-23-BMFRP-IDA

  • up to USD$530,000 over 3 years
  • pre-applications due 21 June 2023
  • Supports innovative ideas and high-impact approaches based on scientifically sound evidence to move toward the vision to understand and cure bone marrow failure (BMF) diseases.
  • Proposed research should have a high probability of revealing new avenues of investigation.
  • Research project should include a well-formulated, testable hypothesis and a well-developed and articulated research approach.
  • Translational potential should be considered and described
  • Established and Early Career Investigator streams
  • may include preliminary data
  • clinical trials not allowed
  • must address at least one focus area


Investigator-Initiated Research Award
HT9425-23-BMFRP-IIRA

  • up to USD4675,000 for 3 years (FL1) or up to USD$850,000 for 2 years
  • pre-proposals due 21 June 2023
  • FL1 – Supports studies that further develop mature ideas, expand upon key discoveries, and have the potential to make significant advances in BMF research and patient care. Correlative studies to
    existing clinical trials/studies are encouraged
  • FL2 – Investigational New Drug (IND)-enabling efforts – Proposed studies should be empirical in nature, product driven,
    and focused on the accumulation of data to support an IND application to the USFDA. Applicants are required to identify lead BMF therapy candidate(s), and transition plans should be
    considered and adequately described. At least one, and no more than three, lead therapeutic candidates must be named at the time of submission.
  • emphasis is on research approach and impact
  • preliminary data required
  • clinical trials not allowed
  • must address at least one focus area

 

2023 Focus Areas

  • Understand the causes and progression of BMF diseases
  • Find effective BMF treatments and cures

 

Relevant BMF Diseases and Conditions

  • Aplastic Anemia
  • Diamond-Blackfan Anemia
  • Dyskeratosis Congenita/Telomere Biology Disorders
  • Fanconi Anemia
  • GATA2 Deficiency
  • Induced BMF: Radiation/Chemical
  • Myelodysplastic Syndromes
  • Paroxysmal Nocturnal Hemoglobinuria
  • Pearson’s Disease
  • SAMD9/SAMD9L Germline Mutations
  • Severe Congenital Neutropenia
  • Shwachman-Diamond Syndrome

 

Read more


Supporting documents for download

Reference Table of Award Mechanisms – 23bmfrpreftable

Idea Development Award –HT9425-23-BMFRP-IDA-GG

Investigator-Initiated Research Award – HT9425-23-BMFRP-IIRA-GG

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