US Dept of Defense – Multiple Sclerosis Research Program

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Clinical Trial Award – HT9425-23-MSRP-CTA

up to USD$1.6M over 3 years (FL1) or USD$4.5M over 4 years (FL2)
preproposal due 8 June 2023
FL1: Supports early-phase, proof-of-principle clinical trials to demonstrate feasibility or inform the design of more advanced trials, or other clinical trials
• FL2: Supports larger-scale clinical trials at phase 1 or 2 that seek to show preliminary evidence of safety or efficacy (benefit on clinical or paraclinical outcomes) in relevant patient populations.
• Scientific rationale and preliminary data required.
preclinical studies not allowed
must address at least one of the following focus areas:
- Promoting Repair, Neuroprotection, and Remyelination in MS
- Treatment of MS Symptoms

Early Investigator Research Award – HT9425-23-MSRP-EIRA

up to USD$320,000 over 2 years
letter of intent due 24 July 2023
must have 1 – 4 years continuous postdoctoral research experience
Supports MS-focused research opportunities for individuals in the early stages of their careers.
Investigator must have a designated mentor who is an experienced MS researcher.
clinical trials not allowed
must address at leasr one of the following focus areas:
- Central Nervous System Repair, Protection, and Regenerative Potential in MS
- Correlates of Disease Activity and Progression in MS
- Biology and Measurement of MS Symptoms
- Factors Contributing to or Associated with MS Etiology, Prodrome, Onset, and Disease Course

Exploration-Hypothesis Development Award – HT9425-23-MSRP-EHDA

up to USD$250,000 over 2 years
pre-applications due 8 June 2023
Supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the MS research field.
New Investigator Option available
preliminary data not required
clinical trials not allowed
must address one of the following focus areas:
- Central Nervous System Repair, Protection, and Regenerative Potential in MS
- Correlates of Disease Activity and Progression in MS
- Biology and Measurement of MS Symptoms
- Factors Contributing to or Associated with MS Etiology, Prodrome, Onset, and Disease Course

Investigator-Initiated Research Award – HT9425-23-MSRP-IIRA

up to USD$1M over 3 years
pre-applications due 8 June 2023
Supports highly rigorous, high-impact research with the potential to make an important contribution to MS research and/or patient care. groundbreaking concepts in the MS research field.
New Investigator Option available
preliminary data required
clinical trials not allowed
must address one of the following focus areas:
- Central Nervous System Repair, Protection, and Regenerative Potential in MS
- Correlates of Disease Activity and Progression in MS
- Biology and Measurement of MS Symptoms
- Factors Contributing to or Associated with MS Etiology, Prodrome, Onset, and Disease Course