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US Dept of Defense – Multiple Sclerosis Research Program

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US Dept of Defense – Multiple Sclerosis Research Program

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Clinical Trial Award  HT9425-23-MSRP-CTA

  • up to USD$1.6M over 3 years (FL1) or USD$4.5M over 4 years (FL2)
  • preproposal due 8 June 2023
  • FL1: Supports early-phase, proof-of-principle clinical trials to demonstrate feasibility or inform the design of more advanced trials, or other clinical trials
    • FL2: Supports larger-scale clinical trials at phase 1 or 2 that seek to show preliminary evidence of safety or efficacy (benefit on clinical or paraclinical outcomes) in relevant patient populations.
    • Scientific rationale and preliminary data  required.
  • preclinical studies not allowed
  • must address at least one of the following focus areas:
    • Promoting Repair, Neuroprotection, and Remyelination in MS
    • Treatment of MS Symptoms


Early Investigator Research Award 
HT9425-23-MSRP-EIRA

  • up to USD$320,000 over 2 years
  • letter of intent due 24 July 2023
  • must have 1 – 4 years continuous postdoctoral research experience
  • Supports MS-focused research opportunities for individuals in the early stages of their careers.
  • Investigator must have a designated mentor who is an experienced MS researcher.
  • clinical trials not allowed
  • must address at leasr one of the following focus areas:
    • Central Nervous System Repair, Protection, and Regenerative Potential in MS
    • Correlates of Disease Activity and Progression in MS
    • Biology and Measurement of MS Symptoms
    • Factors Contributing to or Associated with MS Etiology, Prodrome, Onset, and Disease Course

 

Exploration-Hypothesis Development Award HT9425-23-MSRP-EHDA

  • up to USD$250,000 over 2 years
  • pre-applications due 8 June 2023
  • Supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the MS research field.
  • New Investigator Option available
  • preliminary data not required
  • clinical trials not allowed
  • must address one of the following focus areas:
    • Central Nervous System Repair, Protection, and Regenerative Potential in MS
    • Correlates of Disease Activity and Progression in MS
    • Biology and Measurement of MS Symptoms
    • Factors Contributing to or Associated with MS Etiology, Prodrome, Onset, and Disease Course

Investigator-Initiated Research AwardHT9425-23-MSRP-IIRA

  • up to USD$1M over 3 years
  • pre-applications due 8 June 2023
  • Supports highly rigorous, high-impact research with the potential to make an important contribution to MS research and/or patient care. groundbreaking concepts in the MS research field.
  • New Investigator Option available
  • preliminary data required
  • clinical trials not allowed
  • must address one of the following focus areas:
    • Central Nervous System Repair, Protection, and Regenerative Potential in MS
    • Correlates of Disease Activity and Progression in MS
    • Biology and Measurement of MS Symptoms
    • Factors Contributing to or Associated with MS Etiology, Prodrome, Onset, and Disease Course


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