US Dept of Defense – Peer Reviewed Orthopaedic Research Program

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Applied Research Award – HT9425-PROP-ARA

up to USD$750,000 over 3 years
preproposal due 15 June 2023
Supports applied research applications focused on advancing optimal treatment and restoration of function for individuals with musculoskeletal injuries sustained during combat and service-related activities.
Proposed research should be supported by preliminary and/or published data and have the potential to advance toward clinical translation.
Funding must support preclinical applied research
clinical research and clinical trials not allowed
must address one of the following focus areas:
- Limb Stabilization and Protection
- Retention Strategies (battlefield care or return to duty)
- Osseointegration
- Composite Tissue Regeneration

Clinical Trial Award – HT9425-PROP-CTA

up to USD$12.5M over 4 years (RL1) or USD$3M over 4 years (RL2)
preproposal due 15 June 2023
Supports rapid implementation of clinical
trials with the potential to have a significant
impact on treatment or management of
military combat or service-related orthopaedic
injuries that significantly impact unit
readiness and return to duty/work rates.
must support a clinical trial
animal or preclinical research studies not allowed
must address one of the following focus areas:
- Limb Stabilization and Protection
- Retention Strategies (battlefield care or return to duty)
- Translation of Early Findings (soft tissue trauma or fracture-related infection)
applications addressing Translation of Early Findings – Soft Tissue Trauma and include the Collaborative Care Option are eligible for RL2 funding

Clinical Translational Research Award – HT9425-PROP-CTRA

up to USD$1.5M over 4 years
letters of intent due 15 June 2023
Supports high-impact and/or new/emerging clinical research that may not be ready for a full-scale randomized controlled clinical trial.
must support clinical research studies involving humans
preliminary data required
animal research not allowed
must address one of the following focus areas:
- Retention Strategies (battlefield care or return to duty)
- Volumetric Muscle Loss
- Composite Tissue Regeneration
- Osseointegration
- Prostheses and Orthoses