US Dept of Defense – Traumatic Brain Injury and Psychological Health Research Program

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Clinical Trial Award – HT9425-23-S-TBIPH1

up to USD$500,000 over 3 years (RL1) or up to USD$2M over 4 years (RL2) or up to USD$4M over 4 years (RL3)
Pre-proposals due 15 June 2023
Supports rapid implementation of clinical trials with the potential to have a significant impact on psychological health and/or traumatic brain injury (TBI) through clinical applications, including health care products, technologies, and/or practice guidelines.
application must include Community-Based Participatory Research approaches.
RL1 – Proof-of-principle pilot trials, correlative studies, and other innovative, exploratory clinical trials. Early-Career Partnering Option available.
RL2 – Clinical trials for promising treatments or interventions that have already demonstrated acceptable safety in human subjects.
RL3 – Large-scale clinical trials to demonstrate efficacy in relevant patient populations.

Focused Program Award – HT9425-23-S-TBIPH2

up to USD45M over 4 years
pre-proposals due 15 June 2023
Supports a synergistic, multidisciplinary research program
of at least four distinct but complimentary projects
addressing an overarching goal.
Individual projects must be capable of standing on their
own high scientific merits; they must also be interrelated,
synergistic, and align with an Overarching Challenge to
advance a solution beyond what would be possible
through individual efforts.
Individual research projects may include applied research,
preclinical research, clinical research, and clinical trials.
Proposed research projects should not include basic
research. Research team of highly qualified,
multidisciplinary project leaders should be led by a PI
with demonstrated success in directing large, focused
projects.
Proposal/application must include Community-Based
Participatory Research approaches.

Investigator Initiated Research Award (IIRA) – HT9425-23-TBIPHRP-IIRA

up to USD$500,000 over 3 years
letters of intent due 8 June 2023
Supports research that will make an important contribution
toward understanding, preventing, assessing, and treating
psychological health and/or TBI conditions.
Proposed research projects should not include basic
research.
Early-Career Partnering PI Option is available.
Clinical trials not allowed

Translational Research Award – HT9425-23-TBIPHRP-TRA

up to USD$1M over 4 years
letters of intent due 8 June 2023
Supports translation of promising research into clinical
application (ie preclinical to clinical translation).
May support small-scale pilot clinical trial when necessary
to inform the next step in clinical development.
Partnering PI Option available.

Health Services Research Award – HT9425-23-TBIPHRP-HSRA

up to USD$1.5M over 4 years
letters of intent due 8 June 2023
Supports research to bridge the gap between research, practice, and policy by building a knowledge base on how interventions and clinical practices/guidelines and policies can be deployed to targeted populations at the appropriate time at the point of need.
must support clinical research or clinical trials
preclinical or animal research not allowed.
application must include Community-Based Participatory Research approaches in the development and execution of the clinical research/trial.
may support (not all inclusive)
- Comparative effectiveness research comparing the benefits and harms of emerging or established interventions and strategies to prevent, diagnose, treat, and monitor health conditions in “real-world” settings.
- Development and evaluation of strategies to overcome barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based interventions, tools, policies, and guidelines.
- Analysis of existing data or resources to inform clinical practice.
- Modification of established clinical tools for their intended population or environment.
- Analysis of existing clinical tools to maximize patient-relevant outcomes.
- Identification and analysis of the circumstances that create a need to stop or reduce (“de-implement”) the use of interventions, tools, policies, and guidelines that are ineffective, unproven, low-value, or harmful is within scope